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. 2018 Jan 9;7:e30274. doi: 10.7554/eLife.30274

Figure 3. Meta-analyses of each effect.

Figure 3.

Effect size and 95% confidence interval are presented for Lin et al., 2012, this replication study (RP:CB), and a random effects meta-analysis of those two effects. Cohen’s d is the standardized difference between the two measurements, with a larger positive value indicating total RNA levels are increased at 24 hr compared to 0 hr. The effect size r is a standardized measure of the correlation (strength and direction) of the association between gene expression and c-Myc induction, with a larger positive value indicating gene expression increased during the course of c-Myc induction. Sample sizes used in Lin et al., 2012 and this replication attempt are reported under the study name. (A) Total RNA levels in P493-6 cells 0 hr compared to 24 hr after release from tetracycline (meta-analysis p = 0.0488). (B) Gene expression of active or silent genes are shown for all comparisons. Active genes: 0 hr compared to 1 hr (meta-analysis p = 1.12x10-7), 0 hr compared to 24 hr (meta-analysis p = 7.01x10-4), 1 hr compared to 24 hr (meta-analysis p = 0.0129). Silent genes: 0 hr compared to 1 hr (meta-analysis p = 0.203), 0 hr compared to 24 hr (meta-analysis p = 7.10x10-17), 1 hr compared to 24 hr (meta-analysis p = 0.0571). Additional details for these meta-analyses can be found at https://osf.io/5yscz/.