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. Author manuscript; available in PMC: 2018 Jan 9.
Published in final edited form as: Neuron. 2017 Aug 17;95(5):1074–1088.e7. doi: 10.1016/j.neuron.2017.07.038

Figure 8. Model for the Proposed Mechanism for Depolarization-Induced SV Hyperacidification.

Figure 8

We propose a model for increases in SV acidification and content in DA terminals in response to neuronal stimulation as follows: (1) neuronal depolarization triggers increases in cytoplasmic Na+ concentration; (2) NHE-mediated cation influx into SVs increases vesicle ΔΨ; (3) changes in ΔΨ drive glutamate transport into SVs via VGLUT; (4) the resulting buildup of intraluminal negative charge increases the vesicular proton-motive force, causing the V-ATPase to pump more H+ into the vesicle; and (5) the rise in ΔpH increases the driving force for VMAT-dependent DA loading into SVs.