Table 2.
Total (n=302) | FPC (n=185) | Non-FPC (n=117) | p-value** | ||||
---|---|---|---|---|---|---|---|
N | % | N | % | N | % | ||
All Genes | 36 | 11.9 | 25* | 13.5 | 11 | 9.4 | 0.29 |
| |||||||
Genes Associated with PDAC | |||||||
| |||||||
ATM | 8 | 2.6 | 6 | 3.2 | 2 | 1.7 | |
BRCA1 | 2 | 0.7 | 2 | 1.1 | 0 | 0 | |
BRCA2 | 11 | 3.6 | 8 | 4.3 | 3 | 2.6 | |
CDKN2A (p16) | 4 | 1.3 | 4 | 2.2 | 0 | 0 | |
MSH2 | 1 | 0.3 | 1 | 0.5 | 0 | 0 | |
PALB2 | 1 | 0.3 | 1 | 0.5 | 0 | 0 | |
PMS2 | 1 | 0.3 | 1 | 0.5 | 0 | 0 | |
Subtotal* | 27 | 8.9 | 22* | 11.9 | 5 | 4.3 | 0.02 |
| |||||||
Genes Not Associated with PDAC | |||||||
| |||||||
BARD1 | 1 | 0.3 | 1 | 0.5 | 0 | 0 | |
CHEK2 | 4 | 1.3 | 1 | 0.5 | 3 | 2.6 | |
MUTYH/MYH | 3 | 1.0 | 0 | 0 | 3 | 2.6 | |
NBN | 1 | 0.3 | 1 | 0.5 | 0 | 0 | |
Subtotal | 9 | 3.0 | 3 | 1.6 | 6 | 5.1 | 0.09 |
One FPC case carried two PV: one in BRCA1 and one in BRCA2.
P-value compares prevalence of mutations in FPC versus familial non-FPC probands.