Table 1.
Associations of Coagulation Factor VII Phenotypes with Cardiovascular Disease Risk Factors
| Variable (standard deviation) | FVIIa [mU/mL] β (SE) | P-Value | FVIIa-AT [pM] β (SE) | P-Value |
|---|---|---|---|---|
| Demographic | ||||
| Age (5.2 years) | −0.53 (0.42) | 0.21 | 0.79 (0.94) | 0.40 |
| Female sex | 11.8 (0.85) | <0.0001 | 25.1 (1.9) | <0.0001 |
| African-American race | −4.3 (2.1) | 0.04 | −19.4 (4.7) | <0.0001 |
| Former smoking | 2.1 (0.92) | 0.02 | 3.0 (2.1) | 0.14 |
| Current smoking | 3.4 (1.6) | 0.03 | 11.6 (3.5) | 0.0008 |
| BMI (4.5 kg/m2) | −1.0 (0.42) | 0.02 | −3.5 (0.94) | 0.0002 |
| Hypertension | 1.1 (0.46) | 0.02 | 3.7 (1.0) | 0.0003 |
| Systolic blood pressure (21 mmHg) | 1.8 (0.43) | <0.0001 | 4.8 (0.96) | <0.0001 |
| Diabetes* | −0.93 (1.2) | 0.44 | 4.2 (2.8) | 0.12 |
| Lipids | ||||
| Total-cholesterol (39 mg/dL) | 2.9 (0.43) | <0.0001 | 3.7 (0.97) | 0.0002 |
| HDL-cholesterol (14 mg/dL) | 3.9 (0.45) | <0.0001 | 6.4 (1.0) | <0.0001 |
| LDL-cholesterol (34 mg/dL) | 0.70 (0.42) | 0.10 | 0.74 (0.95) | 0.43 |
| Triglycerides (0.49) | 2.1 (0.42) | <0.0001 | 2.1 (0.94) | 0.03 |
| Inflammation and Coagulation | ||||
| CRP (1.13) | 2.0 (0.42) | <0.0001 | 3.0 (0.94) | 0.002 |
| Platelet count (69 × 103/mm3) | 1.6 (0.44) | 0.0003 | 1.9 (0.97) | 0.05 |
| Fibrinogen (68.6 mg/dL) | −0.12 (0.42) | 0.78 | 1.4 (0.93) | 0.14 |
| FVIIc (26.8 %) | 17.5 (0.34) | <0.0001 | 29.9 (0.87) | <0.0001 |
| FVIIa (25.2 mU/mL) | – | – | 37.3 (0.71) | <0.0001 |
| FVII-AT (56.1 pM) | 17.2 (0.31) | <0.0001 | – | – |
| Subclinical Atherosclerosis | ||||
| Common carotid intima medial thickness† (0.37) | 0.59 (0.47) | 0.21 | 2.9 (1.07) | 0.007 |
| Internal carotid intima medial thickness† (0.20) | −0.21 (0.45) | 0.64 | 2.2 (1.0) | 0.03 |
Associations between FVII phenotypes and biomarkers were estimated in separate linear regression models with FVII as the outcome variable, adjusted for age, sex, and race. Independent variables were modeled per 1-SD increase (values shown in parenthesis); β-coefficients (standard errors) and p-values are presented. Triglycerides, C-reactive protein (CRP), and intima medial thickness (IMT) phenotypes were natural log-transformed. In models of age, sex, and race, the estimates were adjusted only for the 2 remaining variables.
Diabetes models were adjusted for age, sex, race, smoking, BMI, total-cholesterol, HDL-cholesterol, and triglycerides.
IMT models were adjusted for age, sex, race, smoking, BMI, hypertension, systolic blood pressure, total-cholesterol, HDL-cholesterol, and triglycerides.