Table 2.
Top Genome-wide Association Results for FVIIa and FVIIa-AT in European-American Participants of the Cardiovascular Health Study
| Phenotype | Chromosome | Number of SNPs with P<5×10−8 | Candidate genes | Top SNP in region | Closest gene | Position | A1 | A2 | MAF | Beta (SE) | P-Value Top SNP |
|---|---|---|---|---|---|---|---|---|---|---|---|
| FVIIa [mU/mL] | |||||||||||
| 13 | 35 | F7, F10, MCF2L | rs1755685 | F7 | 112805193 | C | A | 0.12 | −25.9 (1.2) | 1.2×10−112 | |
| 20 | 29 | PROCR, EDEM2, TRPC4AP, MYH7B | rs867186 | PROCR | 33228215 | A | G | 0.10 | 7.8 (1.1) | 6.6×10−12 | |
| FVIIa-AT [pM] | |||||||||||
| 13 | 25 | F7, F10, MCF2L, | rs1755685 | F7 | 112805193 | C | A | 0.12 | −26.6 (1.7) | 6.2×10−55 | |
| 20 | 9 | PROCR, EDEM2, | rs867186 | PROCR | 33228215 | A | G | 0.10 | 9.9 (1.7) | 4.7×10−9 |
Positions are for build 36 (hg18). Beta values are presented for A2. SNPs were coded on the forward strand of the genome. A1, allele 1 (major allele); A2, allele 2 (minor allele) ; EDEM2, endoplasmic reticulum degradation-enhancing alpha-mannosidase-like 2; F7, coagulation factor 7; F10, coagulation factor 10; MAF, minor allele frequency; MCF2L, MCF.2 cell line-derived transforming sequence-like; MYH7B, myosin heavy chain 7B; PROCR, protein C receptor; TRPC4AP, transient receptor potential cation channel, subfamily C, member 4 associated protein.