Table 3.

Hazards Ratios for Associations between 1-SD Unit Increases in FVII Phenotypes and Incident Cardiovascular Events and Mortality

	MI (n=576) HR (95% CI)	CHD (n=945) HR (95% CI)	Ischemic Stroke (n=470) HR (95% CI)	CVD-Mortality (n=1,027) HR (95% CI)	All Cause-Mortality (n=2,035) HR (95% CI)
FVIIa
Demographic Model	0.95 (0.87, 1.04)	1.02 (0.95, 1.09)	1.12 (1.02, 1.24)	0.97 (0.91, 1.04)	1.01 (0.97, 1.05)
Risk Factor Model	0.96 (0.88, 1.05)	1.01 (0.94, 1.08)	1.12 (1.01, 1.23)	0.99 (0.92, 1.06)	1.02 (0.98, 1.06)
FVIIa-AT
Demographic Model	1.03 (0.94, 1.12)	1.04 (0.97, 1.11)	1.10 (1.01, 1.20)	1.09 (1.02, 1.17)	1.08 (1.04, 1.12)
Risk Factor Model	1.03 (0.94, 1.13	1.02 (0.95, 1.10)	1.09 (0.99, 1.19)	1.06 (0.99, 1.14)	1.08 (1.03, 1.12)
FVIIc
Demographic Model	1.01 (0.92, 1.11)	1.04 (0.96, 1.12)	1.04 (0.94, 1.16)	0.94 (0.87, 1.01)	0.97 (0.92. 1.01)
Risk Factor Model	0.97 (0.87, 1.07)	1.00 (0.92, 1.08)	1.00 (0.89, 1.12)	0.92 (0.85, 0.99)	0.96 (0.92, 1.01)

Analyses using Cox proportional hazards ratios and 95% confidence intervals (CI) modeled per 1-SD higher FVII phenotype value among participants with each of the FVII phenotypes measured (n=3,427).

Demographic Model: Age, sex, and race.

Risk Factor Model: Age, sex, race, smoking status, diabetes status, hypertension, systolic blood pressure, and LDL-cholesterol; mortality models also included adjustment for prevalent MI, CHD, and stroke at the 1992-93 CHS examination.

CHD, coronary heart disease; CI, confidence interval; HR, hazard ratio; MI, myocardial infarction.