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. Author manuscript; available in PMC: 2019 Feb 1.
Published in final edited form as: Addiction. 2017 Oct 12;113(2):299–312. doi: 10.1111/add.13964

Table 4.

Multilevel Analysis of the Moderating Effects of Baseline Depressive Symptoms on Relations between 1) Stress (t0) and Lapse Risk (t2) and 2) Stress (t0) and Affect (t1). (Long Timeframe: 12-24 hours).

a. The direct effects of stressful event and lapse risk within 24 hours (c path) with and without recent stressful event (t1)

Level-1, Report-Level Coefficient Odds Ratio 95% CI p-value
Level-2, Individual-Level & Cross-Level Interaction Coefficient
Model of t2 Lapse Risk 30 minutes to 24 hours after Index Report (c path)

Random Intercept: Mean Person-level Probability of Smoking at t2a 0.169 (0.079, 0.362) 0.000**
Fagerström Test for Cigarette Dependence 1.175 (0.961, 1.436) 0.116
High Depressive Symptoms (vs. Low) 2.700 (1.087, 6.707) 0.032*
Proportion of Stressful Event Reports 1.03 (0.059, 17.84) 0.086
t0 (Index Report) Stressful Event (Y/N): HD/LDb 2.083/ 0.644 (1.021,4.248)/ (0.326, 1.288) 0.044* /0.216
t0 Stressful Event X High Depressive Symptoms (vs. Low) 3.213 (1.234, 8.369) 0.017*
t-1 Negative Affect 15-min. to 12 hrs. pre-index 1.251 (1.049, 1.493) 0.013*
t-1 Positive Affect 15-min. to 12 hrs. pre-index Random Slope 0.934 (0.745, 1.171) 0.556
t0 (Index Report) Negative Affect 0.800 (0.664, 0.965) 0.020*
t0 (Index Report) Positive Affect 1.032 (0.860, 1.238) 0.737
t1 Recent Smoking Status (between index and t1) Random Slope (Y/N) 2.938 (1.944, 4.441) 0.000**
t0 (Index Report) Smoking within 2hrs. pre-index (Y/N) 2.169 (1.593, 2.954) 0.000**
t-1 Previous Smoking Status (Y/N) 1.713 (1.401, 2.094) 0.000**
Minutes between t0 and t2 Reports Random Slope 1.000 (0.999, 1.001) 0.333

b path - entered into c path model abovec

t1 Negative Affect 15-min. to 12 hrs. post-index- main effect 1.400 (1.184, 1.655) 0.000**
t1 Negative Affect X High Depressive Symptoms (vs. Low) 1.231 (0.896, 1.691) 0.201
t1 Positive Affect 15-min. to 12 hrs. post-index - main effect 1.125 (0.948, 1.337) 0.177
t1 Positive Affect X High Depressive Symptoms (vs. Low) 1.088 (0.774, 1.529) 0.627

Model of t1 Lapse Risk 30 minutes to 24 hours after Index Report (c path) with stressful event at t1

Random Intercept: Mean Person-level Probability of Smoking at t2a 0.058 (0.035, 0.096) 0.000**
Fagerström Test for Cigarette Dependence 1.176 (0.958, 1.443) 0.122
High Depressive Symptoms (vs. Low) 2.805 (1.110, 7.089) 0.029*
Proportion of Stressful Event Reports 1.016 (0.502, 2.059) 0.278
t0 (Index Report) Stressful Event: HD/LDb 1.570/ 0.535 (0.748, 3.296)/ (0.264, 1.084) 0.233/ 0.082
t0 Stressful Event X High Depressive Symptoms (vs. Low) 2.934 (1.108, 7.771) 0.030*
t1 Recent stressful event (within 2 hrs. preceding t1 report: Y/N) 2.358 (1.483, 3.749) 0.000**
t-1 Negative Affect 15-min. to 12 hrs. pre-index 1.245 (1.042, 1.487) 0.016*
t-1 Positive Affect 15-min. to 12 hrs. pre-index Random Slope 0.930 (0.743, 1,165) 0.529
t0 (Index Report) Negative Affect 0.791 (0.654, 0.955) 0.015*
t0 (Index Report) Positive Affect 1.048 (0.873, 1.259) 0.615
t1 Recent Smoking Status (between index and t1) Random Slope (Y/N) 2.703 (1.775, 4.116) 0.000**
t0 (Index Report) Smoking within 2hrs. pre-index (Y/N) 2.201 (1.613, 3.005) 0.000**
t-1 Previous Smoking Status (Y/N) 1.731 (1.292, 2.319) 0.000**
Minutes between t0 and t2 Reports Random Slope 1.000 (0.999,1.001) 0.325
b. The effect of stressful event on negative affect within 2 hours (a path) with and without recent stressful event (t1)

Level-1, Report-Level Coefficient Estimate Standard Error p-value
Level-2, Individual-Level & Cross-Level Interaction Coefficient
Model of t1 Negative Affect 15 minutes to 12 hours after Index Report (a path)

Random Intercept: Mean Negative Affect at t1a 0.139 0.076 0.068
High Depressive Symptoms (vs. Low) 0.223 0.088 0.011*
Proportion of Stressful Event Reports 0.010 0.034 0.005
t0 (Index Report) Stressful Event (Y/N): HD/LDb 0.206/ 0.006 0.073/ 0.006 0.005*/0.915
t0 Stressful Event X High Depressive Symptoms (vs. Low) 0.199 0.092 0.030*
t0 (Index Report): Negative Affect 0.308 0.018 0.000**
t-1 Negative Affect 15-min. to 12 hrs. pre-index Random Slope 0.181 0.021 0.000**
t1 Recent Smoking Status (between index and t1) Random Slope (Y/N) 0.127 0.038 0.000**
t0 (Index Report) Smoking within 2hrs. pre-index Random Slope (Y/N) -0.062 0.046 0.181
t-1 Previous Smoking Status (Y/N) -0.062 0.033 0.059
Minutes between t0 and t1 Reports -0.0001 0.000 0.011*

Model of t1 Negative Affect 15 minutes to 12 hours after Index Report (a path) with stressful event at t1

Random Intercept: Mean Positive Affect at t1a 0.103 0.078 0.086
High Depressive Symptoms (vs. Low) 0.242 0.090 0.007**
Proportion of Stressful Event Reports 0.004 0.004 0.326
t0 (Index Report) Stressful Event (Y/N): HD/LDb 0.040/ 0.112 0.071/ 0.057 0.573/0.033*
t0 Stressful Event X High Depressive Symptoms (vs. Low) 0.082 0.088 0.353
t1 Recent stressful event (within 2 hrs. preceding t1 report: Y/N) 0.780 0.044 0.000**
t0 (Index Report): Negative Affect 0.296 0.017 0.000**
t-1 Negative Affect 15-min. to 12 hrs. pre-index Random Slope 0.173 0.020 0.000**
t1 Recent Smoking Status (between index and t1) Random Slope (Y/N) 0.047 0.036 0.197
t0 (Index Report) Smoking within 2hrs. pre-index Random Slope (Y/N) -0.048 0.042 0.262
t-1 Previous Smoking Status (Y/N) -0.048 0.032 0.131
Minutes between t0 and t1 Reports -0.0001 0.000 0.037*
c. Tde effect of stressful events on positive affect witdin 2 hours (a patd), witd and witdout a recent stressful event (t1) covariate

Level-1, Report-Level Coefficient Estimate Standard Error P-value
Level-2, Individual-Level & Cross-Level Interaction Coefficient
Model of t1 Positive Affect 15 minutes to 12 hours after Index Report (a path)

Random Intercept: Mean Positive Affect at t1a 0.154 0.121 0.203
High Depressive Symptoms (vs. Low) 0.235 0.143 0.076
Proportion of Stressful Event Reports -0.002 0.005 0.688
t0 (Index Report) Stressful Event (Y/N): HD/LDb -0.239/-0.022 0.075/0.059 0.001* /0.709
t0 Stressful Event X High Depressive Symptoms (vs. Low) -0.217 0.094 0.021*
t0 (Index Report): Positive Affect 0.216 0.018 0.000**
t-1 Positive Affect 15-min. to 12 hrs. pre-index Random Slope 0.127 0.020 0.000**
t1 Recent Smoking Status (between index and t1) (Y/N) -0.087 0.036 0.014*
t0 (Index Report) Smoking within 2hrs. pre-index (Y/N) -0.028 -0.038 0.448
t-1 Previous Smoking Status (Y/N) -0.003 0.042 0.942
Minutes between t0 and t1 Reports -0.0000 0.000 0.385

Model of t1 Positive Affect 15 minutes to 12 hours after Index Report (a path) with stressful event at t1

Random Intercept: Mean Positive Affect at t1 a -0.137 0.121 0.261
High Depressive Symptoms (vs. Low) 0.262 0.143 0.067
Proportion of Stressful Event Reports 0.002 0.005 0.689
t0 (Index Report) Stressful Event (Y/N): HD/LDb -0.099/ 0.052 0.075/ 0.059 0.189/0.376
t0 Stressful Event X High Depressive Symptoms (vs. Low) -0.151 0.093 0.105
t1 Recent stressful event (within 2 hrs. preceding t1report: Y/N) -0.412 0.047 0.000**
t0 (Index Report): Positive Affect 0.210 0.018 0.000**
t-1 Positive Affect 15-min. to 12 hrs. pre-index Random Slope 0.125 0.020 0.000**
t1 Recent Smoking Status (between index and t1) (Y/N) -0.043 0.036 0.228
t0 (Index Report) Smoking within 2hrs. pre-index (Y/N) -0.033 0.037 0.371
t-1 Previous Smoking Status (Y/N) -0.009 0.034 0.798
Minutes between t0 and t1 Reports -0.000 0.000 0.236

Note:

The variables that are left aligned are Level-1 (report: within-subject) variables and those that are right aligned are Level-2 (individual: between-subject) variables and cross-level interaction terms.

Proportion of stressful events: this variable was multiplied by 100 before entered into the model in order to interpret the changes in estimate or odds ratio per 1% increment in the proportion of the stressful event reports.

Radom Slope: Specified as a random coefficient. All other predictors were treated as fixed to facilitate model convergence.

t-1 = Report 15 minutes and 12 hours preceding index report t0 = Index report

t1 = Report 15 minutes to 12 hours after index report

t2 = Report 15 minutes to 12 hours after t1 report (& 30 minutes to 24 hours after index report)

a

Mean affect when all variables in the model are at zero (for the continuous variables, zero reflects the overall mean).

b

Models were run twice with different reference groups to estimate simple main effects of stress within LD or HD smokers. The coefficients for stressful events at the index report can be interpreted as the effects of stressful event on smoking within 24 hours among either HD or LD.

c

In order to test the b paths, negative affect and positive affect at index were first entered into the model (presented as main effects) and then cross-level interactions between depressive symptoms (level 2) and affect (level 1) were entered into the model. For simplicity, the other variables in the model are not presented.

*

p<.05,

**

p <.001