Table 2.

Assessment of cardiac abnormalities in mice immunized with or without SERCA2a 971-990 by echo- or electrocardiography

Parameters	Naïve mice	SERCA2a 971-990-immunized mice
Echocardiography
IVSd cm	0.08 ± 0.000	0.08 ± 0.010
LVIDd cm	0.33 ± 0.010	0.34 ± 0.020
LVPWd cm	0.065 ± 0.005	0.064 ± 0.004
LVIDs cm	0.2 ± 0.018	0.224 ± 0.023
EDV (T) ml	0.095 ± 0.009	0.106 ± 0.015
ESV (T) ml	0.025 ± 0.006	0.032 ± 0.009
EF (T) %	76.61 ± 3.855	71.80 ± 4.248
% FS	40.377 ± 3.553	36.014 ± 3.786
SV ml	0.070 ± 0.004	0.074 ± 0.007
LVD Mass ASE (g)	0.660 ± 0.005	0.664 ± 0.006
HR	490.333 ± 11.203	540 ± 13.259
Avg Beats	3.000 ± 0.000	3.000 ± 0.000
Electrocardiography
RR interval (s)	0.120 ± 0.001	0.113 ± 0.001**
Heart rate (BPM)	500.108 ± 5.845	532.258 ± 6.871**
PR interval (s)	0.033 ± 0.001	0.034 ± 0.001
P duration (s)	0.015 ± 0.001	0.015 ± 0.001
QRS interval (s)	0.008 ± 0.000	0.008 ± 0.000
QT interval (s)	0.018 ± 0.001	0.015 ± 0.001*
QTc (s)	0.052 ± 0.003	0.043 ± 0.002*
JT interval (s)	0.010 ± 0.001	0.007 ± 0.000**
Tpeak Tend interval (s)	0.007 ± 0.001	0.004 ± 0.000**
P amplitude (μV)	121.657 ± 17.058	109.677 ± 4.406
Q amplitude (μV)	−25.858 ± 5.745	−24.959 ± 4.156
R amplitude (μV)	713.211 ± 83.796	581.836 ± 25.933
S amplitude (μV)	−36.910 ± 12.329	−98.980 ± 27.776*
ST height (μV)	45.015 ± 12.170	28.783 ± 13.680
T amplitude (μV)	136.547 ± 34.257	179.258 ± 22.088

Data represents mean ± SEM;

^*p ≤ 0.05; and

^**p< 0.01