Table 1.
Deleting all isoforms of leptin receptor (LEPR) in gonadotropes causes infertility.
| Femalea, date of birth | Genotype Lh-cre | # Days with male | # Litters | Average # pups/litter | Total # pups |
|---|---|---|---|---|---|
| F0, 8/19/2015 |
Leprexon 1 f/wt Heterozygous |
65 | 0 | 0 | 0 |
| F6, 8/19/2015 |
Leprexon 1 f/wt Heterozygous |
65 | 0 | 0 | 0 |
| F1, 5/21/2015 |
Leprexon 1 f/f Homozygous |
199 | 6 | 7 | 42 |
| F0, 6/11/2015 |
Leprexon 1 f/f Homozygous |
199 | 4 | 5 | 19 |
| F6, 3/21/2015 |
Leprexon 1 f/f Homozygous |
240 | 0 | 0 | 0 |
| F1, 3/21/2015 |
Leprexon 1 f/f Homozygous |
240 | 0 | 0 | 0 |
| F0, 1/20/2015 |
Leprexon 1 f/f Homozygous |
281 | 0 | 0 | 0 |
aF3-generation females bearing Lh-cre and one or two floxed alleles of Leprexon 1 were bred with males bearing only floxed alleles of Leprexon 1. These seven females came from five different F2-generation litters and three different breeding cages. 71% of these females showed infertility.