Figure 2.

Example AP traces from hVT in control and in the presence of increasing concentrations of tolterodine (A) and terodiline (B) as labeled. Stimulation was applied at a frequency of 1 Hz. Telterodine was tested at concentrations of 0.01, 0.03, 01, and 1 μM (as shown), and terodiline was tested at concentrations of 0.3, 3, 10, and 30 μM (as shown). Calibration: 20 mV; 100 ms. Tolterodine prolonged phase 3 of AP repolarization AP without prominent effects on AP amplitude, while terodiline decreased AP amplitude, shortened phase 2, lengthened phase 3 of repolarization.