Figure 8.

Intraperitoneal (i.p.) treatment with CPT-11 reduced mouse survival rate against bacterial infection. C57BL/6 mice (female, 6–8 weeks old) were first i.p. injected with CPT-11 (200 mg/kg body weight at day 0). Food and water were freely available. At day 7, viable Escherichia coli at a dose of 1 × 10⁹ CFU/mouse was injected into the peritoneal cavity of each mice (including control and vehicle groups). The mice were observed every 6 h for four consecutive days. Kaplan–Meier survival curves were used to analyze the data. The significance was determined by the log-rank (Mantel–Cox) test. n = 10; *P < 0.05; ns, not significant vs control.