Table 1.

Design matrix and results for optimization of the extraction of compounds phenolic.

Run	Variables			Total Phenolic*(mg GAE/100 g)	Total Phenolic Predicted
	Acetone (%)	Water (%)	Ethanol (%)
MIXTURE DESIGN
1	100.0 (1)	0.0 (0)	0.0 (0)	119.81 ± 3.80	120.41
2	0.0 (0)	100.0 (1)	0.0 (0)	155.77 ± 4.90	153.27
3	0.0 (0)	0.0 (0)	100.0 (1)	124.41 ± 6.90	125.40
4	50.0 (½)	50.0 (½)	0.0 (0)	170.32 ± 9.30	170.77
5	50.0 (½)	0.0 (0)	50.0 (½)	124.60 ± 4.20	128.57
6	0.0 (0)	50.0 (½)	50.0 (½)	168.35 ± 10.4	169.22
7	66.7 (2/3)	16.7 (1/6)	16.7 (1/6)	150.90 ± 10.3	147.63
8	16.7 (1/6)	66.7 (2/3)	16.7 (1/6)	166.10 ± 14.70	172.13
9	16.7 (1/6)	16.7 (1/6)	66.7 (2/3)	153.33 ± 2.00	148.79
10 (CP)	33.3 (1/3)	33.3 (1/3)	33.3 (1/3)	171.26 ± 13.6	163.91
11(CP)	33.3 (1/3)	33.3 (1/3)	33.3 (1/3)	155.96 ± 19.89	163.91
12 (CP)	33.3 (1/3)	33.3 (1/3)	33.3 (1/3)	167.14 ± 14.50	163.91
Run	Variables			Total Phenolic*(mg GAE/100 g)	Total Phenolic Predicted
	Time (min)	Temperature (°C)	Agitation speed (rpm)
DOEHLERT DESIGN
1	0 (30.0)	+1.68 (110.0)	0 (150)	111.37 ± 15.45	138.67
2	−1 (20.0)	+1 (90.0)	−1 (50)	173.25 ± 24.17	174.33
3	− (20.0)	+1 (90.0)	+1 (250)	130, 02 ± 44.78	144.31
4	+1 (40.0)	+1 (90.0)	−1 (50)	230.73 ± 51.52	281.00
5	+1 (40.0)	+1 (90.0)	+1 (250)	294.14 ± 45.28	183.20
6	−1.68 (10.0)	0 (60.0)	0 (150)	164.77 ± 6.43	150.91
7 (CP)	0 (30.0)	0 (60.0)	0 (150)	229.56 ± 29.07	261.36
8 (CP)	0 (30.0)	0 (60.0)	0 (150)	268.80 ± 37.90	261.36
9 (CP)	0 (30.0)	0 (60.0)	0 (150)	286.17 ± 76.16	261.36
10	(1.68) 50.0	0 (60.0)	0 (150)	215.13 ± 38.58	228.71
11	−1 (20.0)	−1 (30.0)	−1 (50)	321.61 ± 48.17	269.73
12	−1 (20.0)	−1 (30.0)	+1 (250)	107.47 ± 53.43	171.94
13	+1 (40.0)	−1 (30.0)	−1 (50)	307.03 ± 53.08	308.63
14	+1 (40.0)	−1 (30.0)	+1 (250)	178.68 ± 41.73	210.84
15	0 (30.0)	−1.68 (10.0)	0 (150)	212.42 ± 47.78	184.72

CP, Central Point;

^*Mean ± Standard Deviation.