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. 2017 Oct 23;102(1):85–92. doi: 10.1007/s00223-017-0333-9

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© The Author(s) 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 1 — FGF23 regulates the plasma levels of PTH. a rFGF23 was administered intravenously to normal rats and resulted in a large increase in plasma intact FGF23. b The rFGF23 resulted in a significant decrease in plasma PTH levels after 10 min and the following PTH levels remained low. c Administration of the FGF receptor inhibitor (FGFRi), PD173074, resulted in a significant increase in PTH levels after 4 h. When rFGF23 was given after prior FGFRi, there was no effect of FGF23 on PTH levels. Data are expressed as mean ± SEM. *p < 0.05, **p < 0.01, n = 4 in (a and b), n = 5 in (c)