Skip to main content
. 2018 Jan 9;8:134. doi: 10.1038/s41598-017-18545-x

Table 2.

Immunohistochemical Result of Epithelioid Mesothelioma, Lung Adenocarcinoma, and Squamous Cell Carcinoma.

Antibody Epithelioid Mesothelioma (65 cases) Lung Adenocarcinoma (60 cases) Lung Squamous Cell Carcinoma (56 cases) Z-score!
Positive cases (%) Immunohistochemical Score Positive cases (%) Immunohistochemical Score Positive cases (%) Immunohistochemical Score EM vs LAC EM vs LSC
0 1+ 2+ 3+ 0 1+ 2+ 3+ 0 1+ 2+ 3+
MUC4 0 (0) 65 0 0 0 50 (83.3) 10 20 9 21 50 (89.3) 6 19 10 21 8.0* 8.4*
Calretinin 64 (98.5) 1 5 2 57 17 (28.3) 43 11 6 0 28 (50) 28 13 10 5 9.1* 7.8*
D2–40 63 (96.9) 2 4 5 54 7 (11.7) 53 4 3 0 34 (60.7) 22 7 18 9 9.2* 6.7*
WT1 56 (86.2) 9 17 7 32 0 (0) 60 0 0 0 2 (3.6) 54 2 0 0 9.3* 9.1*
CEA 0 (0) 65 0 0 0 58 (96.7) 2 7 12 39 56 (100) 0 20 21 15 9.3* 9.5*
Claudin 4 0 (0) 65 0 0 0 57 (95) 3 2 10 45 55 (98.2) 1 3 34 18 9.5* 9.2*
TTF-1 0 (0) 65 0 0 0 54 (90) 6 2 6 46 5 (8.9) 51 5 0 0 8.7* 1.01
Napsin-A 0 (0) 65 0 0 0 48 (80) 12 9 3 36 2 (3.6) 54 2 0 0 7.7* 0.34
MOC-31 8 (12.3) 57 5 2 1 55 (91.7) 5 9 8 38 51 (91.1) 5 8 18 25 8.3* 7.8*
P63 15 (23.1) 50 11 3 1 32 (53.3) 28 16 10 6 56 (100) 0 1 2 53 3.2 9.0*
CK5/6 45 (69.2) 20 8 11 26 13 (21.7) 47 6 5 2 55 (98.2) 1 1 5 49 5.2* 4.6*
P40 3 (4.6) 62 3 0 0 6 (10) 54 5 1 0 55 (98.2) 1 0 3 52 0.52 9.1*

WT1: Wilm’s tumor 1; CEA: carcinoembryonic antigen; TTF-1: thyroid transcription factor-1; CK: cytokeratin.

Immunohistochemical score 0: 0% positive cells or trace staining; 1+: 1–10% positive cells; 2+: 11–50% positive cells; 3+: >51% positive cells! The Z-score is calculated by the MannWhitney ‘U’ test between immunohistochemical scores of epithelioid mesothelioma and lung cancer (adenocarcinoma or squamous cell carcinoma).

EM: epithelioid mesothelioma; LAC: lung adenocarcinoma; LSqCC: lung squamous cell carcinoma *significant p-value (<0.0001).