Table 2.
Immunohistochemical Result of Epithelioid Mesothelioma, Lung Adenocarcinoma, and Squamous Cell Carcinoma.
| Antibody | Epithelioid Mesothelioma (65 cases) | Lung Adenocarcinoma (60 cases) | Lung Squamous Cell Carcinoma (56 cases) | Z-score! | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Positive cases (%) | Immunohistochemical Score | Positive cases (%) | Immunohistochemical Score | Positive cases (%) | Immunohistochemical Score | EM vs LAC | EM vs LSC | ||||||||||
| 0 | 1+ | 2+ | 3+ | 0 | 1+ | 2+ | 3+ | 0 | 1+ | 2+ | 3+ | ||||||
| MUC4 | 0 (0) | 65 | 0 | 0 | 0 | 50 (83.3) | 10 | 20 | 9 | 21 | 50 (89.3) | 6 | 19 | 10 | 21 | 8.0* | 8.4* |
| Calretinin | 64 (98.5) | 1 | 5 | 2 | 57 | 17 (28.3) | 43 | 11 | 6 | 0 | 28 (50) | 28 | 13 | 10 | 5 | 9.1* | 7.8* |
| D2–40 | 63 (96.9) | 2 | 4 | 5 | 54 | 7 (11.7) | 53 | 4 | 3 | 0 | 34 (60.7) | 22 | 7 | 18 | 9 | 9.2* | 6.7* |
| WT1 | 56 (86.2) | 9 | 17 | 7 | 32 | 0 (0) | 60 | 0 | 0 | 0 | 2 (3.6) | 54 | 2 | 0 | 0 | 9.3* | 9.1* |
| CEA | 0 (0) | 65 | 0 | 0 | 0 | 58 (96.7) | 2 | 7 | 12 | 39 | 56 (100) | 0 | 20 | 21 | 15 | 9.3* | 9.5* |
| Claudin 4 | 0 (0) | 65 | 0 | 0 | 0 | 57 (95) | 3 | 2 | 10 | 45 | 55 (98.2) | 1 | 3 | 34 | 18 | 9.5* | 9.2* |
| TTF-1 | 0 (0) | 65 | 0 | 0 | 0 | 54 (90) | 6 | 2 | 6 | 46 | 5 (8.9) | 51 | 5 | 0 | 0 | 8.7* | 1.01 |
| Napsin-A | 0 (0) | 65 | 0 | 0 | 0 | 48 (80) | 12 | 9 | 3 | 36 | 2 (3.6) | 54 | 2 | 0 | 0 | 7.7* | 0.34 |
| MOC-31 | 8 (12.3) | 57 | 5 | 2 | 1 | 55 (91.7) | 5 | 9 | 8 | 38 | 51 (91.1) | 5 | 8 | 18 | 25 | 8.3* | 7.8* |
| P63 | 15 (23.1) | 50 | 11 | 3 | 1 | 32 (53.3) | 28 | 16 | 10 | 6 | 56 (100) | 0 | 1 | 2 | 53 | 3.2 | 9.0* |
| CK5/6 | 45 (69.2) | 20 | 8 | 11 | 26 | 13 (21.7) | 47 | 6 | 5 | 2 | 55 (98.2) | 1 | 1 | 5 | 49 | 5.2* | 4.6* |
| P40 | 3 (4.6) | 62 | 3 | 0 | 0 | 6 (10) | 54 | 5 | 1 | 0 | 55 (98.2) | 1 | 0 | 3 | 52 | 0.52 | 9.1* |
WT1: Wilm’s tumor 1; CEA: carcinoembryonic antigen; TTF-1: thyroid transcription factor-1; CK: cytokeratin.
Immunohistochemical score 0: 0% positive cells or trace staining; 1+: 1–10% positive cells; 2+: 11–50% positive cells; 3+: >51% positive cells! The Z-score is calculated by the MannWhitney ‘U’ test between immunohistochemical scores of epithelioid mesothelioma and lung cancer (adenocarcinoma or squamous cell carcinoma).
EM: epithelioid mesothelioma; LAC: lung adenocarcinoma; LSqCC: lung squamous cell carcinoma *significant p-value (<0.0001).