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. 2018 Jan 9;9:104. doi: 10.1038/s41467-017-02371-w

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Reactions catalyzed by multifunctional AusE and PrhA oxygenases. Left block (red) summarizes the reactions catalyzed by AusE or PrhA-V150L/A232S/(M241V) from berkeleyone A (3). Middle block (yellow) summarizes the reactions catalyzed by AusE, PrhA, AusE-L150V/S232A, and PrhA-V150L/A232S/(M241V) from preaustinoid A1 (5). Right block (green) summarizes the reactions catalyzed by PrhA-V150L/A232S/(M241V) from preaustinoid A3 (7) to generate unnatural compounds (13–16). Substrates used to obtain complex structures are circled