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. 2018 Jan 9;8:185. doi: 10.1038/s41598-017-18502-8

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Degradation of mesoporous silica nanoparticles in DMEM. (A) Representative TEM image of mesoporous silica nanoparticles. (B–D) TEM images of original (B), amino group-modified (C) and carboxylic group-modified (D) MSNs in DMEM at 9 h. Scale bars, 200 nm. (E) Plots of the dent depth of MSNs versus time in DMEM. The error bars indicate standard error. The p value in each statistical analysis was less than 0.001.