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. 2018 Jan 9;8:185. doi: 10.1038/s41598-017-18502-8

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Improved silica stability. (A + B) TEM images of larger AgND@SiO₂ after 5 min (A) and 9 h (B) incubation in DMEM. Scale bars, 50 nm. (C) SEM image of the sample in (B). Scale bar, 100 nm. (D) Comparison of luminescence intensity decay of silver nanodots under various conditions. (E–G) EDS images of the above AgND@SiO₂ in PBS showing the signal of silicon (E), potassium (F) and chlorine (G). Scale bars, 250 nm.