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. 2018 Jan 9;8:211. doi: 10.1038/s41598-017-18584-4

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Mn uptake in rat kidney cortex mitochondria depends on the DMT1 genotype.Mitochondria were isolated from two rats of each of 3 genotypes (b/b indicating homozygous Belgrade rats with a G185R mutation, +/b indicating heterozygous rats and +/+ indicating wild-type animals) then incubated with ⁵⁴Mn²⁺ for the times indicated and incorporation was determined. ANOVA for incorporation based on time, genotype or time/genotype interaction indicated differences for each comparison, P < 0.00005 in all cases as well as for all pairwise genotype comparisons. Designating the mean+/+ slope = 1.0, then one +/+ rat’s slope = 1.05; the other +/+ rat’s slope = 0.95; one +/b rat’s slope = 0.56; the other +/b rat’s slope = 0.60; one b/b rat’s slope = 0.25 and the other b/b rat’s slope = 0.14.