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. 2018 Jan 9;9:114. doi: 10.1038/s41467-017-02531-y

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Rapamycin treatment rescues behavioral deficits in Phf8 null mice. a Percentage time spent in each quadrant during the probe trials and representative swim trajectory of each group are evaluated in WT and Phf8 KO mice with vehicle or low-dose rapamycin treatment. (WT/Veh, n = 12; WT/Rap, n = 11; KO/Veh, n = 12; KO/Rap, n = 11; paired two-tailed t-test, *p < 0.05). (Veh, vehicle injection; Rap, rapamycin treatment). b In Barnes maze, latency to reach the target hole is shown during training days. (WT/Rap, n = 11; WT/Veh, n = 12; KO/Rap, n = 10; KO/Veh, n = 10; unpaired two-tailed t-test, *p < 0.05). c Probe trial on day 5 is used to assess spatial memory retention. Number of pokes in target hole during the probe trial (90 s) are calculated and averaged (WT/Rap, n = 11; WT/Veh, n = 12; KO/Rap, n = 10; KO/Veh, n = 10; unpaired two-tailed t-test, *p < 0.05). d Phf8 KO mice show deficit in the passive avoidance test and rapamycin treatment rescues the deficit. The bars indicate the mean latencies to enter the dark chamber on the training day (left) and 24 h later on the retention day (right). (WT/Rap, n = 9; WT/Veh, n = 13; KO/Rap, n = 9; KO/Veh, n = 10; unpaired two-tailed t-test, *p < 0.05, ***p < 0.001)