TABLE 1 .
Comparison of ZIKV IgG antibodies by MIA and neutralizing-antibody titers by PRNT in pre- and postchallenge sera from passively immunized mice
| Characteristics of transferred serum |
De novo prechallenge |
Postchallenge |
||
|---|---|---|---|---|
| High titer | Low titer | High titer | Low titer | |
| MIA MFIa | 4,732b | 219b | 1,422b | 84b |
| PRNT50 | 1,153c | 35c | 153d | 713d |
| Ratio of MFI to PRNT50 titer | 4.1 | 6.3 | 9.3 | 0.1 |
a
ZIKV IgG antibodies were measured using the microsphere immunoassay (MIA) and are expressed as median fluorescence intensities (MFIs).
b
Data are from Fig. 5C.
c
PRNT50s from assays conducted on 1:10 dilutions (in normal BALB/c mouse serum) of serum pools that were used for passive transfer.
d
Data are from Fig. 5D.