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. 2018 Jan 10;3(1):e00580-17. doi: 10.1128/mSphere.00580-17

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Copyright © 2018 Johnson et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

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FIG 1 — Effect of HPV on the expression of Rb-E2F/p53 pathway genes in HNSCCs. (A) Log expression levels of the 25 genes in the Rb-E2F/p53 pathways (see Table S1 in Data Set S1 in the supplemental material) are represented by boxplots. Data for HPV⁺ samples are colored in teal, and data for HPV⁻ samples are in red. (B) The Rb-E2F/p53 pathways in HPV⁺ tumors. The CDKN2A gene produces differentially spliced transcripts for the p16 and ARF proteins. Red, upregulated; green, downregulated; black, no significant difference.