TABLE 3 .

ERG-based HNSCC subgroup summary

	Description for tumors that were:
	HPV− with:		HPV+
Parameter	Low ERG expression	High ERG expression
ERG RNA levels	Low number of ERGs upregulated	High number of ERGs upregulated; distributionsimilar to that in HPV+subgroup	High number of ERGs upregulated
Clinical associations	NAa	Correlated with higher tumor grades and lymph node involvement	Correlated with higher tumor grades and lymph node involvement; highly present in base of tongue and tonsil, better vital status, more associated with males
Genomewide pathway analysis	Uniquely upregulated genes associated with ectoderm development and keratin, cytoskeleton, and protein complex assembly	NA	NA

^aNA, not applicable.