Table 3.
Determination of atorvastatin in Lipitor® tablets (20 mg) by the proposed spectrofluorimetric methods.
Spectrofluorimetric method using acetate buffer (pH 3.4) |
Spectrofluorimetric method using 5% acetic acid |
Spectrofluorimetric method using methanol |
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Known concentration (μg/mL) | Concentration found (μg/mL) | Recovery (%) | Known concentration (μg/mL) | Concentration found (μg/mL) | Recovery (%) | Known concentration (μg/mL) | Concentration found (μg/mL) | Recovery (%) |
2.00 | 1.97 | 98.62 | 2.00 | 1.99 | 99.75 | 1.00 | 1.03 | 102.92 |
2.50 | 2.59 | 103.44 | 3.00 | 3.02 | 100.60 | 1.50 | 1.47 | 98.03 |
3.00 | 3.15 | 105.10 | 4.00 | 4.02 | 100.53 | 2.00 | 1.96 | 98.18 |
3.50 | 3.59 | 102.67 | 2.50 | 2.54 | 101.47 | |||
4.00 | 3.99 | 99.95 | 3.00 | 3.12 | 104.09 | |||
Mean | 101.96 | 100.29 | 100.94 | |||||
N | 5.00 | 3.00 | 5.00 | |||||
SD | 2.64 | 0.47 | 2.75 | |||||
R.S.D. (%) | 1.16 | 0.27 | 1.22 |