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. 2012 Feb 3;2(4):298–305. doi: 10.1016/j.jpha.2012.01.010

Table 5.

Forced degradation studies of Letrozole.

Stress conditions Drug recovered* (%) Drug decomposed* (%)
Standard drug 100.0 -
Acidic hydrolysis 96.4 3.6
Alkaline hydrolysis 42.1 57.9
Oxidative degradation 99.2 0.8
Thermal degradation 95.0 5.0
Photolytic degradation 100.0 -
*

Mean of three replicates.