Table 1.
Mass parameters of sibutramine (SB) and its two metabolites N-des methyl sibutramine (DSB), N-di des methyl sibutramine (DDSB) and sibutramine d7 (SB d7), N-des methyl sibutramine d7 (DSB d7), N-di des methyl sibutramine d7 (DDSB d7).
| Compound name | Transition of precursor molecular ion to product ion |
Compound dependent parameters (V) |
|||||
|---|---|---|---|---|---|---|---|
| Precursor molecular ion (m/z) | Product ion (m/z) | Run time (min) | EP | DP | CE | CXP | |
| Sibutramine | 280.3 | 124.9 | 9.2 | 10 | 30 | 35 | 12 |
| N-desmethyl sibutramine | 266.3 | 125.3 | 8.2 | 10 | 28 | 30 | 12 |
| N-di des methyl sibutramine | 252.2 | 124.9 | 6.2 | 10 | 35 | 32 | 12 |
| Sibutramine d7 | 287.3 | 125.2 | 9.1 | 10 | 40 | 38 | 12 |
| N-des methyl sibutramine d7 | 273.2 | 125.0 | 8.1 | 10 | 36 | 40 | 12 |
| N-di des methyl sibutramine d7 | 259.3 | 125.1 | 6.2 | 10 | 23 | 39 | 12 |
EP: entrance potential, DP: declustering potential, CE: collisional energy and CXP: collisional cell exit potential.