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Test vs. reference pharmacokinetic parameters of sibutramine, N-des methyl sibutramine and N-di des methyl sibutramine after administration of 15 mg of test and reference products in 40 healthy human volunteers.
| Pharmacokinetic parameters | Test/reference |
||
|---|---|---|---|
| Sibutramine | N-des methyl sibutramine | N-di des methyl sibutramine | |
| Cmax | 93.1 | 99.0 | 102.2 |
| AUC0–t | 92.1 | 91.9 | 95.6 |
| AUC0–∞ | 83.9 | 91.8 | 95.1 |
