Table 3.
Stability of MC in plasma samples.
| Stability | Spiked plasma concentration (ng/mL) | Concentration measured (ng/mL) (mean±SD; n=6) | RSDa (%) (n=6) |
|---|---|---|---|
| Room temperature stability (24.5 h) | 3.00 | 2.85±0.26 | 9.14 |
| 300.00 | 298.07±13.36 | 4.48 | |
| Processed sample stability (71.5 h) | 3.00 | 3.08±0.09 | 2.84 |
| 300.00 | 310.46±8.09 | 2.60 | |
| Long term stability (55 days) | 3.00 | 3.03±0.09 | 2.95 |
| 300.00 | 295.41±3.38 | 1.15 | |
| Freeze–thaw stability (cycle 3, 48 h) | 3.00 | 2.86±0.20 | 7.10 |
| 300.00 | 297.11±7.46 | 2.51 |
a
(Standard deviation/mean concentration measured)×100.