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. Author manuscript; available in PMC: 2018 Oct 17.
Published in final edited form as: Biochemistry. 2017 Oct 3;56(41):5476–5480. doi: 10.1021/acs.biochem.7b00795

Figure 1.

Figure 1

Structures of CYP2C9 and allelic variants in complex with losartan: (A) Structure of CYP2C9 WT (yellow) complexed with three molecules of losartan (orange sticks). (B) Structure of CYP2C9 *3 (orange) with two molecules of losartan (cyan sticks). (C) Structure of CYP2C9 *30 (green) in complex with three losartan molecules (pink sticks) in similar orientation and location to that in the WT complex. Heme is in red sticks.Location of each losartan is represented by red numbers: 1, peripheral site; 2, active site; and 3, access channel.