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. Author manuscript; available in PMC: 2018 Oct 17.
Published in final edited form as: Biochemistry. 2017 Oct 3;56(41):5476–5480. doi: 10.1021/acs.biochem.7b00795

Figure 4.

Figure 4

SNP in CYP2C9 *30. The *30 complex (green) associated with A477T substitution on the β4 loop is superimposed on the CYP2C9 WT complex (yellow) with losartan. The Q214 sidechain in the WT complex interacts with the imidazole ring of losartan, and rotates ∼180° in the *30 complex to hydrogen bond (yellow dashes) with the polar threonine substitution at 477. Losartans (spheres) are numbered in red.