Table 2.
Inter-day and intra-day precision and accuracy of the method for candesartan and hydrochlorothiazide.
| Analyte | Level | Concentration added (ng/mL) | Inter-day (n=6) |
Intra-day (n=18) |
||||
|---|---|---|---|---|---|---|---|---|
| Mean conc. found (ng/mL) | Nominal (%) | CV (%) | Mean conc. found (ng/mL) | Nominal (%) | CV (%) | |||
| Candesartan | LLOQQC | 1.00 | 1.03 | 102.67 | 4.95 | 1.03 | 102.67 | 4.65 |
| LQC | 2.75 | 2.72 | 98.91 | 3.26 | 2.68 | 97.41 | 4.13 | |
| MQC | 249.66 | 235.09 | 94.16 | 2.56 | 245.21 | 98.22 | 3.88 | |
| HQC | 411.44 | 386.78 | 94.01 | 2.87 | 402.50 | 97.83 | 3.67 | |
| Hydrochloro-thiazide | LLOQQC | 1.00 | 1.00 | 100.17 | 7.04 | 1.00 | 100.17 | 6.62 |
| LQC | 2.74 | 2.66 | 97.02 | 4.67 | 2.70 | 98.52 | 3.71 | |
| MQC | 301.90 | 292.56 | 96.91 | 2.39 | 305.45 | 101.17 | 4.12 | |
| HQC | 495.12 | 468.15 | 94.55 | 3.20 | 483.36 | 97.62 | 3.16 | |