Table 4.
Pharmacokinetic parameters after administration of immediate release CN+HCT (32+25 mg) tablets in human subjects (n=59).
| Pharmacokinetic parameters | Candesartan |
Hydrochlorothiazide |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Test |
Reference |
90% CI for T/R a | Test |
Reference |
90% CI for T/Ra | |||||
| Mean | RSD (%) | Mean | RSD (%) | Mean | RSD (%) | Mean | RSD (%) | |||
| Cmax(ng/mL) | 353.04 | 118.73 | 296.82 | 84.85 | 112.31–124.51 | 164.79 | 41.71 | 167.84 | 38.46 | 92.35–102.85 |
| AUC0−t (ng h/mL) | 3079.21 | 824.71 | 2581.70 | 588.34 | 112.99–123.60 | 1039.96 | 213.62 | 1023.37 | 223.78 | 99.62–103.96 |
| AUC0−∞ (ng h/mL) | 3128.76 | 835.57 | 2631.63 | 593.35 | 112.67–123.09 | 1083.58 | 217.33 | 1066.47 | 221.92 | 99.65–103.70 |
a
90% Confidence interval for the ratio of the mean test/reference.