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. 2018 Jan 10;16:2. doi: 10.1186/s12967-017-1375-5

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Hypoxia-responsive network in the placenta. miR-20a and miR-210 expression is upregulated via HIF1α. These miRNAs in turn regulate a broad spectrum of genes under hypoxia, including genes involved in mitochondrial biogenesis (ISCU), the respiratory chain (COX10), DNA double strand break repair (RAD52) and cell death (PTEN). miR-20a and miR-210 have both been shown to target HIF1α itself as well