Table 4.
Within (columns) and between (lines) group comparisons of WOMAC Total score (%)
| Curamin mean ± SD | Placebo mean ± SD | Curamed mean ± SD | Intergroup comparison, mean difference or difference in rank sum$ and p values | ||
|---|---|---|---|---|---|
| Placebo vs Curamin | Placebo vs Curamed | ||||
| Visit 1 Baselinea | 33.06 ± 15.56 N = 67 | 30.37 ± 15.21 N = 68 | 28.94 ± 13.20 N = 66 |
−2.69 p > 0.05 |
1.43 p > 0.05 |
| Visit 2a | 27.91 ± 16.2 N = 63 | 26.89 ± 13.9 N = 65 | 24.34 ± 14.44 N = 60 | −1.02 p > 0.05 |
2.55 p > 0.05 |
| Visit 3a | 26.49 ± 17.0 N = 61 |
28.13 ± 15.57 N = 59 | 21.86 ± 14.36 N = 58 |
1.64 p > 0.05 |
6.27 p > 0.05 |
| Within group Comparisonb |
P < 0.0001¥ N = 61 |
P > 0.05 N = 59 |
P < 0.05 N = 58 |
||
| Effect Sizea d Cohen , g Hedges |
−0.404 | −0.146 | --0.515 | ||
| Confidence interval | −0.754 − −0.054 | −0.495 − 0.204 | −0.873 − −0.156 | ||
| Mean change from baseline to Visit 2a | 5.65 ± 6.97*** N = 63 |
3.65 ± 7.04*** N = 65 |
4.31 ± 8.75*** N = 60 |
−2.00 P > 0.05 |
−0.65 P > 0.05 |
| Mean change from baseline to Visit 3a | 7.38 ± 10.02*** N = 61 |
2.26 ± 10.39 N = 59 |
6.34 ± 11.38*** N = 58 |
−5.12
−24.84 $ P < 0.05* |
−4.08
−17.18 $ P > 0.05 |
Within group comparison:
aIntention to treat analysis of all patients - One sample matched-pair t-test or Wilcoxon non-parametric test, * - p < 0.05, ** - p < 0.01, *** - p < 0.001
bPatients completed all tests – repeated measures ANOVA or Friedman’s test¥
Between groups comparison: One-way independent- measures ANOVA with post hoc Dunnett’s Multiple Comparison Test or Kruskal-Wallis test with post hoc Dunns Test$,
Effect size for mean differences of groups with different sample size; http://www.psychometrica.de/effect_size.html#anova. Confidence Coefficient – 95%