Table 4.

Multivariate analysis of mortality according to management strategy

Variable	In-hospital mortality			1-year mortality
	HR	95% CI	P value	HR	95% CI	P value
Surgical patients
Age (years)				1.04	1.00 to 1.08	0.03
EuroSCORE II	1.00	1.00 to 1.01	0.28	–	–	–
Serum eGFR (mL/min)*				0.98	0.96 to 0.99	0.005
Serum haemoglobin (g/dL)*				0.99	0.98 to 1.00	0.05
Serum neutrophils (×109/L)*				1.02	0.92 to 1.12	0.74
Serum CRP (mg/L)*	1.01	1.0 to 1.02	0.07	1.01	1.00 to 1.01	0.12
Predisposing cardiac disease†				1.81	0.31 to 10.45	0.51
Intervention (12 months)‡				0.30	0.07 to 1.34	0.12
Native valve				0.36	0.15 to 0.90	0.03
Positive blood culture				0.74	0.25 to 2.23	0.60
Valvular abscess	2.30	0.54 to 9.78	0.26	1.46	0.50 to 4.26	0.49
Renal failure§	4.01	1.01 to 16.07	0.05	1.36	0.27 to 6.95	0.71
Left-sided IE	0.46	0.09 to 2.38	0.35
Time to surgery	1.13	1.06 to 1.20	0.03	1.11	1.05 to 1.17	0.001
Medical patients
Age (years)				1.02	0.98 to 1.07	0.32
Serum neutrophils (×109/L)*	1.08	0.90 to 1.31		1.21	1.04 to 1.41	0.02
Positive blood culture	0.11	0.02 to 0.64		0.44	0.11 to 1.73	0.24
Acute stroke	2.32	0.35 to 15.49	0.38	12.30	3.04 to 49.72	<0.0001
Duration of inpatient stay				1.00	0.99 to 1.01	0.89
ET				0.24	0.07 to 0.87	0.03

All demographic, clinical and outcome data (apart from mortality) were first entered into a univariate model (online supplementary tables 1 and 2), and those found to be significant at a level of P<0.20 were then entered into a stepwise forward multivariate model.

*Admission values.

†Rheumatic disease, prosthetic valve or valve repair.

‡Dental or surgical interventions within the past 12 months.

§Renal failure requiring renal replacement therapy.

CRP, C-reactive protein; eGFR, estimated glomerular filtration rate; ET, endocarditis team; EuroSCORE, European System for Cardiac Operative Risk Evaluation; IE, infective endocarditis.