Table 4.
Number of proteins in proteomics analysis, per ontology category, statistically compared between TOF and VSD RV samples
| Proteins (n) | Percentage of total unique proteins (2357) | ||||||||
| Ontology | Category | Total | No change | Higher TOF | Lower TOF | Total | No change | Higher TOF | Lower TOF |
| Total number of accession numbers | 3610 | 3410 | 174 | 26 | |||||
| Total number of unique proteins | 2357 | 2244 | 100 | 13 | 100 | 95.2 | 4.2 | 0.6 | |
| Molecular function | Antioxidant activity | 13 | 13 | 0 | 0 | 0.6 | 0.6 | 0.0 | 0.0 |
| Binding | 643 | 607 | 34 | 2 | 27.3 | 25.8 | 1.4 | 0.1 | |
| Catalytic activity | 806 | 776 | 25 | 5 | 34.2 | 32.9 | 1.1 | 0.2 | |
| Channel regulator activity | 4 | 4 | 0 | 0 | 0.2 | 0.2 | 0.0 | 0.0 | |
| Receptor activity | 36 | 32 | 4 | 0 | 1.5 | 1.4 | 0.2 | 0.0 | |
| Signal transducer activity | 14 | 13 | 0 | 1 | 0.6 | 0.6 | 0.0 | 0.0 | |
| Structural molecule activity | 234 | 217 | 15 | 2 | 9.9 | 9.2 | 0.6 | 0.1 | |
| Translation regulator activity | 21 | 20 | 1 | 0 | 0.9 | 0.8 | 0.0 | 0.0 | |
| Transporter activity | 101 | 95 | 5 | 1 | 4.3 | 4.0 | 0.2 | 0.0 | |
| Biological process | Biological adhesion | 54 | 53 | 1 | 0 | 2.3 | 2.2 | 0.0 | 0.0 |
| Biological regulation | 162 | 156 | 4 | 2 | 6.9 | 6.6 | 0.2 | 0.1 | |
| Cellular component organisation or biogenesis | 335 | 319 | 12 | 4 | 14.2 | 13.5 | 0.5 | 0.2 | |
| Cellular process | 1014 | 965 | 42 | 7 | 43.0 | 40.9 | 1.8 | 0.3 | |
| Developmental process | 158 | 149 | 7 | 2 | 6.7 | 6.3 | 0.3 | 0.1 | |
| Growth | 1 | 1 | 0 | 0 | 0.0 | 0.0 | 0.0 | 0.0 | |
| Immune system process | 81 | 75 | 6 | 0 | 3.4 | 3.2 | 0.3 | 0.0 | |
| Localisation | 310 | 295 | 13 | 2 | 13.2 | 12.5 | 0.6 | 0.1 | |
| Locomotion | 15 | 14 | 1 | 0 | 0.6 | 0.6 | 0.0 | 0.0 | |
| Metabolic process | 939 | 900 | 34 | 5 | 39.8 | 38.2 | 1.4 | 0.2 | |
| Multicellular organismal process | 137 | 130 | 5 | 2 | 5.8 | 5.5 | 0.2 | 0.1 | |
| Reproduction | 24 | 22 | 1 | 1 | 1.0 | 0.9 | 0.0 | 0.0 | |
| Response to stimulus | 169 | 158 | 9 | 2 | 7.2 | 6.7 | 0.4 | 0.1 | |
| Cell component | Cell junction | 14 | 1 | 0 | 0.6 | 0.6 | 0.0 | 0.0 | |
| Cell part | 709 | 675 | 30 | 4 | 30.1 | 28.6 | 1.3 | 0.2 | |
| Extracellular matrix | 20 | 20 | 0 | 0 | 0.8 | 0.8 | 0.0 | 0.0 | |
| Extracellular region | 64 | 63 | 1 | 0 | 2.7 | 2.7 | 0.0 | 0.0 | |
| Macromolecular complex | 282 | 268 | 12 | 2 | 12.0 | 11.4 | 0.5 | 0.1 | |
| Membrane | 149 | 144 | 5 | 0 | 6.3 | 6.1 | 0.2 | 0.0 | |
| Organelle | 440 | 417 | 20 | 3 | 18.7 | 17.7 | 0.8 | 0.1 | |
| Synapse | 5 | 5 | 0 | 0 | 0.2 | 0.2 | 0.0 | 0.0 | |
| Protein class | Calcium-binding protein | 62 | 60 | 2 | 0 | 2.6 | 2.5 | 0.1 | 0.0 |
| Cell adhesion molecule | 38 | 35 | 3 | 0 | 1.6 | 1.5 | 0.1 | 0.0 | |
| Cell junction protein | 18 | 18 | 0 | 0 | 0.8 | 0.8 | 0.0 | 0.0 | |
| Chaperone | 49 | 49 | 0 | 0 | 2.1 | 2.1 | 0.0 | 0.0 | |
| Cytoskeletal protein | 167 | 153 | 12 | 2 | 7.1 | 6.5 | 0.5 | 0.1 | |
| Defense/immunity protein | 31 | 29 | 2 | 0 | 1.3 | 1.2 | 0.1 | 0.0 | |
| Enzyme modulator | 200 | 195 | 4 | 1 | 8.5 | 8.3 | 0.2 | 0.0 | |
| Extracellular matrix protein | 39 | 38 | 1 | 0 | 1.7 | 1.6 | 0.0 | 0.0 | |
| Hydrolase | 189 | 180 | 9 | 0 | 8.0 | 7.6 | 0.4 | 0.0 | |
| Isomerase | 41 | 39 | 2 | 0 | 1.7 | 1.7 | 0.1 | 0.0 | |
| Ligase | 56 | 56 | 0 | 0 | 2.4 | 2.4 | 0.0 | 0.0 | |
| Lyase | 38 | 36 | 2 | 0 | 1.6 | 1.5 | 0.1 | 0.0 | |
| Membrane traffic protein | 69 | 67 | 2 | 0 | 2.9 | 2.8 | 0.1 | 0.0 | |
| Nucleic acid binding | 320 | 306 | 12 | 2 | 13.6 | 13.0 | 0.5 | 0.1 | |
| Oxidoreductase | 165 | 164 | 1 | 0 | 7.0 | 7.0 | 0.0 | 0.0 | |
| Receptor | 52 | 48 | 4 | 0 | 2.2 | 2.0 | 0.2 | 0.0 | |
| Signalling molecule | 79 | 76 | 3 | 0 | 3.4 | 3.2 | 0.1 | 0.0 | |
| Storage protein | 1 | 1 | 0 | 0 | 0.0 | 0.0 | 0.0 | 0.0 | |
| Structural protein | 20 | 17 | 1 | 2 | 0.8 | 0.7 | 0.0 | 0.1 | |
| Surfactant | 1 | 1 | 0 | 0 | 0.0 | 0.0 | 0.0 | 0.0 | |
| Transcription factor | 72 | 67 | 5 | 0 | 3.1 | 2.8 | 0.2 | 0.0 | |
| Transfer/carrier protein | 64 | 61 | 3 | 0 | 2.7 | 2.6 | 0.1 | 0.0 | |
| Transferase | 170 | 161 | 8 | 1 | 7.2 | 6.8 | 0.3 | 0.0 | |
| Transmembrane receptor regulatory/adaptor protein | 10 | 10 | 0 | 0 | 0.4 | 0.4 | 0.0 | 0.0 | |
| Transporter | 81 | 77 | 3 | 1 | 3.4 | 3.3 | 0.1 | 0.0 | |
| Viral protein | 0 | 0 | 0 | 0 | 0.0 | 0.0 | 0.0 | 0.0 | |
The total number of proteins, and number significantly changed, or not, between pathologies are shown. Proteins are also shown as a percentage of the number of unique proteins. The ontology categories with the five highest percentage of proteins per pathology are given in bold.
RV, right ventricle; TOF, tetralogy of Fallot; VSD, ventricular septal defect.