Table 3.
Prevalence and incidence rates of comorbidities observed among patients with psoriatic arthritis
| Comorbid condition† | Psoriatic arthritis population (n=94 302) |
Continuously enrolled population* (n=47 438) | Psoriatic arthritis population (n=94 302) |
Continuously enrolled population* (n=47 438) |
||
| Prevalence‡, n (%) | Incidence§, n (%) | Rate per 100 patient-years | Incidence§, n (%) | Rate per 100 patient-years |
||
| Hyperlipidaemia¶ | 44 768 (47.47) | 23 811 (50.19) | 23 156 (35.0) | 27.11 | 8202 (30.02) | 21.31 |
| Hypertension¶ | 44 583 (47.28) | 23 447 (49.43) | 20 599 (31.25) | 23.91 | 6773 (24.25) | 17.15 |
| Depression | 19 995 (21.2) | 10 656 (22.46) | 12 853 (15.44) | 10.16 | 5671 (14.34) | 9.50 |
| Type 2 diabetes mellitus¶ | 19 037 (20.19) | 10 036 (21.16) | 11 794 (13.49) | 8.72 | 5558 (13.14) | 8.57 |
| Fibromyalgia | 15 635 (16.58) | 8306 (17.51) | 10 453 (12.36) | 8.07 | 4848 (11.96) | 7.94 |
| Obesity¶ | 15 510 (16.45) | 8331 (17.56) | 8742 (10.65) | 7.05 | 3425 (8.69) | 5.78 |
| Ischaemic heart disease¶ | 10 918 (11.58) | 6005 (12.66) | 7256 (8.10) | 5.19 | 3704 (8.44) | 5.54 |
| Cardiac dysrhythmias¶ | 9756 (10.35) | 5510 (11.62) | 6819 (7.73) | 5.01 | 3022 (7.05) | 4.66 |
| Osteoporosis | 8802 (9.33) | 4665 (9.83) | 6415 (7.16) | 4.63 | 3017 (6.85) | 4.56 |
| Peripheral vascular disease | 7298 (7.74) | 4202 (8.86) | 6275 (6.91) | 4.40 | 3352 (7.49) | 4.94 |
| Infections** | 7159 (7.59) | 4058 (8.55) | 5656 (6.26) | 3.98 | 2967 (6.66) | 4.37 |
| Cerebrovascular disease¶ | 6903 (7.32) | 3953 (8.33) | 5478 (6.02) | 3.84 | 2829 (6.31) | 4.14 |
| Major depression | 6686 (7.09) | 3655 (7.7) | 4730 (5.14) | 3.27 | 2391 (5.23) | 3.43 |
| Solid tumours, including melanoma | 5963 (6.32) | 3340 (7.04) | 4343 (4.80) | 3.04 | 2098 (4.69) | 3.08 |
| Gout | 5673 (6.02) | 3278 (6.91) | 3757 (4.12) | 2.62 | 1789 (3.97) | 2.60 |
| Non-alcoholic liver disease | 5440 (5.77) | 2930 (6.18) | 3587 (3.88) | 2.46 | 1780 (3.86) | 2.53 |
| Chronic renal insufficiency | 4867 (5.16) | 2637 (5.56) | 3466 (3.85) | 2.44 | 1777 (4.00) | 2.63 |
| Non-melanoma skin cancers | 3707 (3.93) | 2069 (4.36) | 3041 (3.29) | 2.08 | 1548 (3.36) | 2.21 |
| Congestive heart failure | 3698 (3.92) | 2157 (4.55) | 2852 (3.07) | 1.94 | 1539 (3.32) | 2.18 |
| Atherosclerosis¶ | 3355 (3.56) | 1942 (4.09) | 2803 (3.02) | 1.91 | 1524 (3.3) | 2.16 |
| Uveitis | 1466 (1.55) | 790 (1.67) | 949 (1.02) | 0.64 | 424 (0.91) | 0.59 |
| Ulcerative colitis | 1206 (1.28) | 656 (1.38) | 801 (0.86) | 0.54 | 365 (0.778) | 0.51 |
| Haematological malignancies | 1079 (1.14) | 604 (1.27) | 771 (0.82) | 0.52 | 412 (0.88) | 0.57 |
| Crohn’s disease | 1070 (1.13) | 604 (1.27) | 626 (0.67) | 0.42 | 303 (0.64) | 0.42 |
| Acute myocardial infarction**†† | 524 (0.56) | 292 (0.62) | 506 (0.54) | 0.34 | 281 (0.59) | 0.39 |
| Suicide and suicidal ideation | 453 (0.48) | 253 (0.53) | 434 (0.46) | 0.29 | 245 (0.52) | 0.34 |
| Any stroke**‡‡ | 445 (0.47) | 255 (0.54) | 420 (0.45) | 0.28 | 234 (0.49) | 0.32 |
| Ischaemic stroke**‡‡ | 342 (0.36) | 198 (0.42) | 332 (0.35) | 0.22 | 189 (0.40) | 0.26 |
*Continuous enrolment with a minimum of 12 months: 6 months before the index date and 6 months after the index date.
†Includes all claims and any diagnosis field unless specified otherwise.
‡Prevalence is the proportion of occurrences for the specific comorbidity during the study period divided by the total population.
§Incidence is the proportion of new occurrences of the specific comorbidity divided by the population at risk for developing the comorbidity after the index date (ie, patients who had a claim for the comorbidity before the index date are excluded).
¶Medical conditions that can be associated with an increased risk of major adverse cardiac event.
**Includes only serious medical conditions (ie, those with an inpatient diagnosis).
††Acute myocardial infarction was based on the inpatient primary discharge diagnosis claims (ie, the primary discharge diagnosis).
‡‡Cases that likely represent a major adverse cardiac event.