Skip to main content
. Author manuscript; available in PMC: 2018 Jan 10.
Published in final edited form as: Stroke. 2011 Nov 23;43(2):514–523. doi: 10.1161/STROKEAHA.111.627562

Figure 3.

Figure 3

Aβ effects on tight junction (TJ) proteins and MMPs in brain microvessels. Western blots showing concentration-dependent (A) reduction of the TJ proteins claudin-1 and claudin-5 and (B) increase of the matrix metalloproteases MMP-2 and MMP-9 in rat brain microvessels exposed to human Aβ40 for 6 hours. Expression of the TJ proteins ZO-1 and occludin remained unchanged. C, Zymogram showing increased MMP-9 activity in isolated brain microvessels that were exposed to 100 nmol/L Aβ40 for 6 hours. Aβ indicates amyloid-β.