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. Author manuscript; available in PMC: 2018 Jan 10.
Published in final edited form as: Stroke. 2011 Nov 23;43(2):514–523. doi: 10.1161/STROKEAHA.111.627562

Figure 5.

Figure 5

Permeability of brain microvessels from hAPP mice. Efflux of the fluorescence dye Texas red (TR) was monitored over 60 minutes in microvessels from wild-type and hAPP mice with/without mannitol used as positive control for barrier opening. Data are mean±SEM for 7 brain microvessels per time point from 1 microvessel isolation from 20 mice; SEM are in the range 3.1 to 11.4. Shown are arbitrary units (0–255). First-order efflux rates were calculated using nonlinear regression. hAPP indicates human amyloid precursor protein.