Table.

Summary of Patient Data

Patient No.	Age, y	Sex	Hypertension	Diabetes Mellitus	Microbleeds	Lobar Bleeds	Additional MRI Findings	WMC	Apolipoprotein E	Additional Information
1*	84	F	−	+	>5	>3	SH, BBB leakage	Severe	N/P	Rapid-onset dementia, malignant course, angiography negative
2	61	M	+	+	11	2	2 acute lacunar ischemia	Severe	N/P	…
3	74	M	+	−	3	1	Acute lacunar ischemia	Mild	ε3/ε4	Focal seizures
4	73	F	+	−	3	0	SH, PRES	Severe	ε3/ε4	Angiography negative, focal seizures,
5	78	M	+	−	>20	1	SDH	Mild	N/P	Mild cognitive impairment, incidental cerebral and abdominal aneurysm
6*	71	M	+	+	>20	>2	PRES, BBB leakage	Severe	ε3/ε3	PRES, BBB leakage Asymptomatic, occipital bleeds/WMC, angiography negative
7	75	M	−	−	>7	1	SH	Severe	N/P	Acute and old severe SH, mild cognitive impairment, complex partial seizures
8	78	F	−	+	5	0	SH	Mild	ε3/ε3	Mild cognitive impairment
9	85	F	−	−	>20	1	…	Mild	ε3/ε4	Occipital bleeds/WMC
10	70	M	+	−	>40	0	…	Severe	N/P	Microbleeds cortical and subcortical, mild hypertension, dementia >7 y
11	83	F	−	−	0	2	SDH	Moderate	N/P	…
12	78	M	−	−	2	0	SH	Mild	ε2/ε3	Focal seizures, additional old basal ganglia hemorrhage
13	84	F	+	−	0	2	…	Mild	N/P	SH due to severe lobar cortical hemorrhage
14	74	M	+	−	>20	3	…	Moderate	ε3/ε4	Generalized seizure, status postembolic ischemia due to AF
15	66	M	+	−	8	0	Acute lacunar infarct	Moderate	ε2/ε4	Mild cognitive impairment, angiography negative
16	80	F	+	−	1	3	…	Moderate	N/P	SH due to severe lobar cortical hemorrhage
17	65	F	+	−	8	…	Acute lacunar infarct	Mild	N/P	Chemotherapy due to mamma carcinoma
18	81	M	−	−	7	2	SH	Moderate	N/P	…
19	74	F	+	−	12	2	SH	Mild	N/P	AF, malignant melanoma, rapid CAA

WMCs indicates white matter changes; F, female; M, male; SH, superficial hemosiderosis; BBB, blood– brain barrier; PRES, posterior reversible encephalopathic syndrome; SDH, subdural hematoma; N/P, not performed; CAA, cerebral amyloid angiopathy.

^*Patient 1 is represented in Figure 1; Patient 6 is represented in Figure 2.