Table 1.
Patient Demographics and Clinical Characteristics
| T790M Positive | T790M Negative | p value | ||
|---|---|---|---|---|
| Total number of patients | 69 | 28 | ||
| Age (mean ± standard deviation) | 65.2 ± 11.3 | 70.3 ± 11.5 | p = 0.052 | |
| Gender | ||||
| Male | 22 | 6 | p = 0.30 | |
| Female | 47 | 22 | ||
| Ethnicity | ||||
| Caucasian | 13 | 11 | p = 0.14 | |
| Black | 1 | 0 | ||
| Asian | 22 | 4 | ||
| Hispanic | 5 | 2 | ||
| Other | 5 | 0 | ||
| Unknown | 23 | 11 | ||
| Smoking Status | ||||
| Current or Former Smoker | 18 | 4 | p = 0.21 | |
| Never Smoker | 51 | 24 | ||
| EGFR Mutation | ||||
| Exon 19 Deletion | 43 | 15 | p = 0.57 | |
| L858R | 20 | 10 | ||
| Exon 19 Deletion and L858R | 2 | 0 | ||
| Unknown | 4 | 3 | ||
| Stage | ||||
| IV at Diagnosis | 58 | 25 | p = 0.51 | |
| Recurrent | 11 | 3 | ||
| Tumor Histology | ||||
| Adenocarcinoma | 67 | 26 | p = 0.28 | |
| Squamous Cell Carcinoma | 0 | 1 | ||
| Adenosquamous Carcinoma | 2 | 1 | ||
| Data Analysis | ||||
| By RECIST | 51 | 25 | ||
| By Medical chart | 18 | 3 | ||
| Treated with first-line TKI | 66 | 28 | ||
| Treated with TKI rechallenge | 29 | 14 | ||
| Treated with chemotherapy | 42 | 18 | ||