Table 2.

Univariable and Multivariable Cox Proportional Hazard Regression Analysis for Progression-Free Survival on First-line TKI

Parameter	Univariable Analysis		Multivariable Analysis
	p value	Hazard Ratio (95% Confidence Interval)	p value	Hazard Ratio (95% Confidence Interval)
T790M mutation: negative vs positive	0.10	1.46 (0.93–2.29)	0.021	1.75 (1.09–2.82)
TKI: in combination vs alone	0.57	1.22 (0.61–2.44)		N/A
TKI: before vs after chemotherapy	0.015	2.02 (1.14–3.56)		N/A
Sex: male vs female	0.021	0.59 (0.37–0.92)	0.010	1.88 (1.16–3.03)
Race: Caucasian vs Asian	0.58	1.19 (0.65–2.16)		N/A
Race: Other vs Asian	0.64	1.18 (0.59–2.36)		N/A
Age as continuous variable (as 1 year increase)	0.90	1.00 (0.98–1.02)		N/A
Smoking status: yes vs no	0.007	1.99 (1.21–3.29)	0.011	1.93 (1.16–3.20)
Exon 19 deletion: absent vs present	0.25	1.31 (0.83–2.06)		N/A
L858R: present vs absent	0.13	1.41 (0.90–2.22)		N/A
Stage: recurrent vs advanced at presentation	0.45	1.28 (0.68–2.41)		N/A