Table 4.
Univariable and Multivariable Cox Proportional Hazard Regression Analysis for Progression-Free Survival on Chemotherapy
| Parameter | Univariable Analysis | Multivariable Analysis | ||
|---|---|---|---|---|
| p value | Hazard Ratio (95% Confidence Interval) | p value | Hazard Ratio (95% Confidence Interval) | |
| T790M mutation: negative vs positive | 0.025 | 1.95 (1.09–3.49) | 0.025 | 1.95 (1.09–3.49) |
| Chemotherapy: after vs before TKI | 0.036 | 1.87 (1.04–3.34) | N/A | N/A |
| Sex: female vs male | 0.14 | 1.50 (0.88–2.55) | N/A | N/A |
| Race: Caucasian vs Asian | 0.99 | 1.00 (0.50–1.98) | N/A | N/A |
| Race: Other vs Asian | 0.25 | 0.63 (0.28–1.40) | N/A | N/A |
| Age as continuous variable (as 1 year increase) | 0.40 | 1.01 (0.99–1.03) | N/A | N/A |
| Smoking status: yes vs no | 0.91 | 1.04 (0.55–1.94) | N/A | N/A |
| Exon 19 deletion: absent vs present | 0.94 | 1.02 (0.59–1.77) | N/A | N/A |
| L858R: present vs absent | 0.63 | 1.15 (0.65–2.03) | N/A | N/A |
| Stage: recurrent vs advanced at presentation | 0.40 | 0.69 (0.30–1.63) | N/A | N/A |