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. Author manuscript; available in PMC: 2018 Nov 1.
Published in final edited form as: Dev Dyn. 2017 Sep 25;246(11):925–945. doi: 10.1002/dvdy.24579

Figure 9.

Figure 9

Conserved syntenies illuminate gsdf history. A. Part of zebrafish chromosome Dre21 (A1) compared to spotted gar chromosome Loc2 (A2) shows that genes to the right of gsdf in zebrafish and gar are conserved, but an indel to the left of gsdf in zebrafish disrupts syntenies. B. Comparing gar Loc2 (B3) to human Hsa4 (B4) shows a break that disrupts the expected location of a human gsdf ortholog. The gar gsdf region on Loc2 (B3) is paralogous to the gdf9 region on gar chromosome Loc6 (B2), which in turn is orthologous to the GDF9 region of human chromosome Hsa5 (B1), as predicted for paralogs. C. A dot plot identifying paralogs of Hsa5 genes on other human chromosomes shows that AFF gene family members, which are adjacent or nearly adjacent to gsdf, bmp15, and gdf9, occupy paralogous human chromosome segments, as expected by ohnologs from the vertebrate genome duplication VGD2.