Figure 4.

Stress pathway activation in tau transgenic animals. A, Neurons with activated JNK signaling as monitored by the puc-lacZ reporter and immunostaining for β-galactosidase, which is directed to the nucleus (Bier et al., 1989), in flies expressing tau using the pan-neuronal elav-GAL4 driver. Arrows indicate positive nuclei. Scale bar, 10 μm. B, Quantitative analysis of the number of neurons with activated JNK in the entire brains of control animals, or in flies expressing human wild-type or FTDP-17 mutant forms of tau. Six brains were analyzed per genotype. Control is elav-GAL4/+; puc-lacZ/+. Full genotypes are provided in Figure 4-1. Flies are 30 d old. **p < 0.01, ANOVA with Tukey's HSD. Full statistical analysis is presented in Figure 4-1.