Figure 2.
Acute treatment with KN93, but not KN92, reversed mechanical allodynia and thermal hyperalgesia in EAE. Separate groups of 8 mice received KN93 (45 nmol, i.t.), KN92 (45 nmol, i.t.), or saline once on Day 8 after inducing EAE with immunization with MOG35–55 on Day 0. A, B, Acute administration of KN93 (45 nmol, i.t.) significantly reversed the mechanical allodynia (A) and thermal hyperalgesia (B) in EAE mice. KN92 has no effect on the mechanical and thermal sensitivities. Data are expressed as the mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001 compared with the sham group; #p < 0.05, ##p < 0.01 compared with the saline-treated EAE group.