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. 2018 Jan 3;38(1):232–244. doi: 10.1523/JNEUROSCI.2666-17.2017

Figure 6.

Figure 6.

Absence of EAE-induced mechanical allodynia and thermal hyperalgesia in CaMKIIαT286A mutant mice. CaMKIIα T286A point mutant mice or wild-type littermates were immunized with MOG35–55 to induce EAE. A, CaMKIIα T286A point mutant mice developed a significantly lower degree of motor dysfunction. B, C, Mechanical allodynia (B) and thermal hyperalgesia (C) were absent in CaMKIIα T286A point mutant mice with EAE. Data are expressed as the mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001 compared with the sham immune CaMKIIα wild-type mice; #p < 0.05, ##p < 0.01, ###p < 0.001 compared with CaMKIIα wild-type mice developed with EAE.