Figure 7.
Absence of EAE-induced nonevoked ongoing pain in CaMKIIαT286A point mutant mice. A, Lidocaine produced CPP in wild-type mice with EAE, but CaMKIIαT286A point mutant mice with EAE showed no chamber preference, compared with saline-treated wild-type mice. ***p < 0.001 compared with saline paired chamber. B, Difference scores (test time − preconditioning time in each chamber) confirmed that wild-type mice with EAE, but not CaMKIIαT286A point mutant mice with EAE, exhibited CPP to lidocaine. *p < 0.05, **p < 0.01 test time compared with preconditioning time. Data are expressed as the mean ± SEM.