Figure 8.

Effects of pretreatment and acute treatment with IL-17 antiserum in EAE-induced hyperalgesia. Groups of mice were injected with IL-17 antiserum or vehicle 24 and 2 h before immunization and on Day 1 to Day 3 p.i. A, B, Mice treated with vehicle developed less and delayed mechanical (A) and thermal (B) hyperalgesia. C, D, Acute treatment of IL-17 antiserum on Day 8 p.i. had no effect on mechanical (C) or thermal (D) hyperalgesia in EAE mice. Data are expressed as the mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001 compared with the sham immune group; #p < 0.05, ##p < 0.01, ###p < 0.001 compared with the vehicle-treated EAE group.