Figure 9.

Spinal CaMKIIα mediates IL-17-induced hyperalgesia. A, B, Groups of mice were intrathecally injected with IL-17 or vehicle and 24 h later were injected with KN93 or vehicle. IL-17-induced mechanical and thermal hyperalgesia in mice and the injection of KN93 reversed the developed hyperalgesia. C, D, Groups of wild-type and CaMKIIα mutant mice were injected with IL-17. Twenty-four hours later, IL-17-induced mechanical and thermal hyperalgesia is absent in CaMKIIα mutant mice. Data are expressed as the mean ± SEM. *p < 0.05, **p < 0.01 compared with the IL-17-treated CaMKIIα wild-type mice; #p < 0.05, ###p < 0.001 compared with the vehicle-treated IL-17 group.