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Study schematic. Arrows indicate overnight CRU admissions for frequent blood sampling to measure LH levels. Participants took E2 (1 mg daily) and P4 (0.5 mg/kg three times daily) between admissions 1 and 2 and again between admissions 3 and 4. After admission 2, the metformin dose was increased weekly by 500 mg/d until participants were using 1000 mg twice daily. *75 g OGTT performed at 7:00 am on the days of discharge from admissions 1 and 3.
